http://dspace.bsu.edu.ru/handle/123456789/64201| Title: | CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the Gnao1 for safety studies of RNA therapeutics |
| Authors: | Polikarpova, A. V. Egorova, T. V. Lunev, E. A. Tsitrina, A. A. Vassilieva, S. G. Deykin, A. V. |
| Keywords: | medicine medical genetics medical genomics genetically modified mice genome editing CRISPR/Cas9 personalized medicine GNAO1 encephalopathy |
| Issue Date: | 2023 |
| Citation: | CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the Gnao1 for safety studies of RNA therapeutics / A.V. Polikarpova, T.V. Egorova, E.A. Lunev [et al.] // Frontiers in Genome Editing. - 2023. - Vol.5.-Art. 1034720. - Doi: 10.3389/fgeed.2023.1034720. |
| Abstract: | In this work, CRISPR/Cas9 technology was used to introduce a monobase substitution in exon 6 of the Gnao1 gene to replace the mouse triplet encoding Gly203 (GGG) with a codon used in the human gene (GGA) |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/64201 |
| Appears in Collections: | Статьи из периодических изданий и сборников (на иностранных языках) = Articles from periodicals and collections (in foreign languages) |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Polikarpova_CRISPRCas9-generated mouse_23.pdf | 2.87 MB | Adobe PDF | View/Open |
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