http://dspace.bsu.edu.ru/handle/123456789/46672| Название: | Synthesis, molecular docking, ADMET study and in vitro pharmacological research of 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione as a promising non-opioid analgesic drug |
| Авторы: | Kravchenko, A. D. Pyatigorskaya, N. V. Brkich, G. E. Yevsieieva, L. V. Kyrychenko, A. V. |
| Ключевые слова: | medicine pharmacology antagonist drug discovery ion channels molecular docking TRPA1 TRPV1 non-opioid analgesic drug |
| Дата публикации: | 2022 |
| Библиографическое описание: | Synthesis, molecular docking, ADMET study and in vitro pharmacological research of 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione as a promising non-opioid analgesic drug / A.D. Kravchenko [et al.] // Research Results in Pharmacology. - 2022. - Vol.8, №1.-P. 1-11. - Doi: 10.3897/rrpharmacology.8.80504. |
| Краткий осмотр (реферат): | The discovery of novel drugs that can block the transmission of pain signals for treating the pain of various etiologies is an urgent topic in pharmaceutics. The aim of this paper is to synthesize and to investigate in vitro and in silico characteristics of a promising novel compound: 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione (HSV-DKH-0450) |
| URI (Унифицированный идентификатор ресурса): | http://dspace.bsu.edu.ru/handle/123456789/46672 |
| Располагается в коллекциях: | Vol. 8, № 1 |
| Файл | Описание | Размер | Формат | |
|---|---|---|---|---|
| Kravchenko_Synthesis.pdf | 2.35 MB | Adobe PDF | Просмотреть/Открыть |
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