http://dspace.bsu.edu.ru/handle/123456789/46540| Title: | Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs |
| Authors: | Bogus, S. K. Kulikov, A. L. Vinakov, D. V. Suzdalev, K. P. Galenko-Yaroshevskii, P. A. |
| Keywords: | medicine pharmacology vagus nerve neurogenic atrial fibrillation indole derivate SS-68 antiarrhythmic action pharmacokinetics |
| Issue Date: | 2016 |
| Citation: | Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs / S. K. Bogus [et al.] // Research result: pharmacology and clinical pharmacology. - 2016. - Vol. 2, № 3.- P. 3-10. - Doi: 10.18413/2500-235X-2016-2-3-3-10. - Refer.: p. 9-10. |
| Abstract: | It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this substance, since the suppression of the AF coincides with its anticholinergic effect observed for more than 2 hours, but cardiotropic action at this time was not observed. High antiarrhythmic activity of SS-68 to neurogenic AF may be due to the IKAch inhibition and blockade of M2-cholinergic receptors |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46540 |
| Appears in Collections: | Vol. 2, № 3 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Bogus_Anticholinergic_16.pdf | 1.07 MB | Adobe PDF | View/Open |
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