Anti-osteoporotic action research of nanoparticulated resveratrol and losartan

Abstract

The study demonstrated eight weeks after ovariectomy in female white Wistar rats endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone develops, leading to the emergence of generalized osteoporosis. Nanoparticulated forms of losartan and resveratrol, possessing endothelium protective action, effectively prevents the reduction of regional microcirculation in bone tissue, keeping it at the level of intact rats