http://dspace.bsu.edu.ru/handle/123456789/63428| Title: | Synthesis and pharmacological activity of various organic and inorganic salts of phenyl derivatives of imidazobenzimidazole |
| Authors: | Zhukovskaya, O. N. Eliseeva, N. V. Vassiliev, P. M. Pridvorov, G. V. Grechko, O. Yu. |
| Keywords: | medicine pharmacology imidazobenzimidazole derivatives kappa-opioid agonists nociceptive neuropathic pain opioid analgesics quantum chemical modeling |
| Issue Date: | 2024 |
| Citation: | Synthesis and pharmacological activity of various organic and inorganic salts of phenyl derivatives of imidazobenzimidazole / O.N. Zhukovskaya, N.V. Eliseeva, P.M. Vassiliev [et al.] // Research Results in Pharmacology. - 2024. - Vol.10, №2.-P. 119-133. - Doi: 10.18413/rrpharmacology.10.465. - Refer.: p. 132. |
| Abstract: | The creation of new opioid analgesics that are devoid of the main undesirable effects - euphoria, respiratory depression, tolerance - is an important task for the treatment of pain syndrome. Eighteen salts of 9-pyrrolidinoethyl-(1a), 9-piperidinoethyl-(1b), and 9-morpholinoethyl-2-(4- fluorophenyl)benzo[d]imidazo[1,2-a]imidazole (1c) were synthesized and tested for kappa agonist and analgesic activity |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/63428 |
| Appears in Collections: | Vol. 10, № 2 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Zhukovskaya_Synthesis_24.pdf | 667.55 kB | Adobe PDF | View/Open |
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