http://dspace.bsu.edu.ru/handle/123456789/46602| Title: | Study of aversive and p38 mapk-inhibitory properties of kappa-agonist with analgesic activity-compound RU-1205 |
| Authors: | Spasov, A. A. Zvartau, E. E. Grechko, O. I. Eliseeva, N. V. Semenova, Yu. V. |
| Keywords: | medicine pharmacology dysphoria kappa-opioid receptor p38 MAPK-kinase butorphanol morphine |
| Issue Date: | 2020 |
| Citation: | Study of aversive and p38 mapk-inhibitory properties of kappa-agonist with analgesic activity-compound RU-1205 / A.A. Spasov [et al.] // Research Results in Pharmacology. - 2020. - Vol.6, №3.-P. 59-65. - Doi: 10.3897/rrpharmacology.6.54558. |
| Abstract: | The clinical use of kappa-opioid agonists, despite their lack of significant drug potential, is limited by the development of severe sedation, dysphoria, depression, and anhedonia. To this date, there are kappa-opioid receptor agonists lacking these side effects due to the selective activation of intracellular signal transmission pathways without p38-MAPK-kinase activation |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46602 |
| Appears in Collections: | Vol. 6, № 3 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Spasov_Study of aversive.pdf | 746.96 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.