http://dspace.bsu.edu.ru/handle/123456789/46308| Title: | Efficacy of liposomal dosage forms and hyperosmolar salines in experimental pharmacotherapy of acute lung injury |
| Authors: | Kulikov, O. A. Ageev, V. P. Marochkina, E. E. Dolgacheva, I. S. Minayeva, O. V. |
| Keywords: | medicine pharmacology N-acetylcysteine acute lung injury aprotinin Cyanine-7 dexamethasone HyperHAES hypertonic saline liposomes |
| Issue Date: | 2019 |
| Citation: | Efficacy of liposomal dosage forms and hyperosmolar salines in experimental pharmacotherapy of acute lung injury / O.A. Kulikov [et al.] // Research Results in Pharmacology. - 2019. - Vol. 5, № 2.- P. 23-41. - Doi: 10.3897/rrpharmacology.5.35529. - Refer.: p. 39-40. |
| Abstract: | Hypertonic sodium chloride solutions and liposomal drugs with pulmotropic effect are of great interest for the treatment of acute lung injury (ALI). For the experiment, liposomes with dexamethasone, N-acetylcysteine (NAC), aprotinin and dye Cyanine-7 (Cy-7) were obtained. A liposome analysis was performed by means of spectrophotometry. ALI was modeled in rats by the administration of the damaging agents into the trachea. All the studied therapeutic agents increased the survival rate of the laboratory animals with ALI. The most effective experimental agent was liposomal dexamethasone |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/46308 |
| Appears in Collections: | Vol. 5, № 2 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kulikov_Efficacy.pdf | 4.71 MB | Adobe PDF | View/Open |
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