http://dspace.bsu.edu.ru/handle/123456789/62664| Title: | Identification and synthesis of metabolites of the new antiglaucoma drug |
| Authors: | Khokhlov, A. L. Yaichkov, I. I. Korsakov, M. K. Shetnev, A. A. Ivanovskiy, S. A. |
| Keywords: | medicine pharmacology biotransformation selective carbonic anhydrase II inhibitor HPLC-MS/MS N-hydroxysulfonamide Nacetylsulfonamide isoxazole sulfonamide |
| Issue Date: | 2024 |
| Citation: | Identification and synthesis of metabolites of the new antiglaucoma drug / A.L. Khokhlov, I.I. Yaichkov, M.K. Korsakov [et al.] // Research Results in Pharmacology. - 2024. - Vol.10, №1.-P. 53-66. |
| Abstract: | The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5- (trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide. Identification and synthesis of metabolite substances are necessary for subsequent tests of bioavailability, linearity of pharmacokinetics, accumulation, distribution and excretion |
| URI: | http://dspace.bsu.edu.ru/handle/123456789/62664 |
| Appears in Collections: | Vol. 10, № 1 |
| File | Description | Size | Format | |
|---|---|---|---|---|
| Khokhlov_Identification_24.pdf | 677.15 kB | Adobe PDF | View/Open |
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