| DC Field | Value | Language |
|---|
| dc.contributor.author | Kubekina, M. V. | - |
| dc.contributor.author | Silaeva, Yu. Yu. | - |
| dc.contributor.author | Bruter, A. V. | - |
| dc.contributor.author | Kolesnik, I. M. | - |
| dc.contributor.author | Korokin, M. V. | - |
| dc.date.accessioned | 2022-05-11T08:16:25Z | - |
| dc.date.available | 2022-05-11T08:16:25Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.citation | Transgenic mice Cre-dependently expressing mutant polymerase-gamma: novel test-system for pharmacological study of mitoprotective drugs / M.V. Kubekina [et al.] // Research Results in Pharmacology. - 2021. - Vol.7, №3.-P. 33-39. - Doi: 10.3897/rrpharmacology.7.72784. | ru |
| dc.identifier.uri | http://dspace.bsu.edu.ru/handle/123456789/46649 | - |
| dc.description.abstract | PolG-alpha is a nuclear-encoded enzyme which provides replication and repair of mitochondrial DNA. D257A mutation of PolG-alpha leads to change in the N-terminal "proofreading" domain, which deprives the enzyme of 3′-5′ exonuclease activity, resulting in accumulation of mutations in the mitochondrial genome | ru |
| dc.language.iso | en | ru |
| dc.subject | medicine | ru |
| dc.subject | pharmacology | ru |
| dc.subject | Cre-LoxP system | ru |
| dc.subject | genome editing | ru |
| dc.subject | IVF | ru |
| dc.subject | mitochondrial polymerase-gamma | ru |
| dc.subject | transgenic mice | ru |
| dc.title | Transgenic mice Cre-dependently expressing mutant polymerase-gamma: novel test-system for pharmacological study of mitoprotective drugs | ru |
| dc.type | Article | ru |
| Appears in Collections: | Vol. 7, № 3
|
