| DC Field | Value | Language |
|---|
| dc.contributor.author | Skachilova, S. Y. | - |
| dc.contributor.author | Ragulina, V. A. | - |
| dc.contributor.author | Kostina, D. A. | - |
| dc.contributor.author | Burda, Y. E. | - |
| dc.date.accessioned | 2022-05-04T10:26:37Z | - |
| dc.date.available | 2022-05-04T10:26:37Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.citation | Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine / S.Y. Skachilova [et al.] // Research result: pharmacology and clinical pharmacology. - 2017. - Vol. 3, № 2.- P. 50-56. - Doi: 10.18413/2313-8971-2017-3-2-50-56. | ru |
| dc.identifier.uri | http://dspace.bsu.edu.ru/handle/123456789/46569 | - |
| dc.description.abstract | At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were: mexidol, ethoxidol and the agent under the code XS-9. Further inhibitory activity against NF-κB pharmacological agents was studied on 4 models: L-NAME-induced endothelial dysfunction, staphylococcal sepsis, acute toxic liver damage and acute pancreatitis | ru |
| dc.language.iso | en | ru |
| dc.subject | medicine | ru |
| dc.subject | pharmacology | ru |
| dc.subject | Nuclear factor kappa B | ru |
| dc.subject | NF-κB | ru |
| dc.subject | 3-hydroxypyridine derivatives | ru |
| dc.subject | pharmacological correction | ru |
| dc.title | Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-κB: focus on the derivatives of 3- hydroxypyridine | ru |
| dc.type | Article | ru |
| Appears in Collections: | Vol. 3, № 2
|
