Laser-assisted fabrication and in vitro verification of functionalized surface for cells biointegration

Abstract

The paper investigates how the surface relief of an implant affects cell behavior. Currently, most implant manufacturers claim the key impact biocompatibility factor to be surface micro-roughness. We suppose that the interaction between cells and implants also depends on such relief peculiarities as continuous or discontinuous topography, subcellular distance between peaks and presence of porous oxide layer. We have developed the laser processing conditions that provide three different reliefs: "open grooves", "grid" and "close grooves". Along with the micro-roughness characteristics the reliefs differ with their deepness and period of grooves