DSpace Collection: http://dspace.bsuedu.ru/handle/123456789/62343 2026-04-07T13:54:10Z Synthesis and pharmacological activity of various organic and inorganic salts of phenyl derivatives of imidazobenzimidazole http://dspace.bsuedu.ru/handle/123456789/63428 Title: Synthesis and pharmacological activity of various organic and inorganic salts of phenyl derivatives of imidazobenzimidazole Authors: Zhukovskaya, O. N.; Eliseeva, N. V.; Vassiliev, P. M.; Pridvorov, G. V.; Grechko, O. Yu. Abstract: The creation of new opioid analgesics that are devoid of the main undesirable effects - euphoria, respiratory depression, tolerance - is an important task for the treatment of pain syndrome. Eighteen salts of 9-pyrrolidinoethyl-(1a), 9-piperidinoethyl-(1b), and 9-morpholinoethyl-2-(4- fluorophenyl)benzo[d]imidazo[1,2-a]imidazole (1c) were synthesized and tested for kappa agonist and analgesic activity 2024-01-01T00:00:00Z Study of the neuroprotective properties of the heteroreceptor EPOR/CD131 agonist of peptide structure in tau-proteinopathy modeling http://dspace.bsuedu.ru/handle/123456789/63427 Title: Study of the neuroprotective properties of the heteroreceptor EPOR/CD131 agonist of peptide structure in tau-proteinopathy modeling Authors: Stepenko, Yu. V.; Shmigerova, V. S.; Kostina, D. A.; Shcheblykina, O. V.; Zhernakova, N. I.; Solin, A. V.; Koroleva, N. V.; Markovskaya, V. A.; Dudnikova, O. V.; Bolgov, A. A. Abstract: Tau proteinopathy is a pathology associated with the activation of post-translational modifications and interactions of pathophysiological cascades of neuroinflammation with hyperphosphorylation of Tau aggregates. Therefore, preference is given to agents that have properties in reducing or slowing down the processes of neuroinflammation and post-translational modifications in the brain 2024-01-01T00:00:00Z Approaches to therapy Amlodipine/Indapamide/ Perindopril therapy of high arterial hypertension in ischemic heart disease patients with chronic kidney disease stage 1-3 after coronary stenting http://dspace.bsuedu.ru/handle/123456789/63426 Title: Approaches to therapy Amlodipine/Indapamide/ Perindopril therapy of high arterial hypertension in ischemic heart disease patients with chronic kidney disease stage 1-3 after coronary stenting Authors: Pribylov, S. A.; Leonidova, K. O.; Pribylov, V. S.; Gavrilyuk, E. V.; Pribylova, N. N. Abstract: The aim of the study was to analyze the dynamics of vascular stiffness, pulmonary hypertension (PH), diastolic heart dysfunction and endothelial dysfunction indices in patients with different variants of ischemic heart disease combined with chronic kidney disease (CKD) stage 1-3 using complex therapy of combined hypotensive drug Amlodipine/ Indapamide/Perindopril three months after coronary stenting and to compare them with the group of patients on conservative therapy only 2024-01-01T00:00:00Z Assessment of VEGF and TNF-alpha levels in patients with an unexpectedly poor and suboptimal response during the treatment of infertility using ART methods http://dspace.bsuedu.ru/handle/123456789/63425 Title: Assessment of VEGF and TNF-alpha levels in patients with an unexpectedly poor and suboptimal response during the treatment of infertility using ART methods Authors: Perfilova, V. N.; Muzyko, E. A.; Tikhaeva, K. Yu.; Kustova, M. V.; Mukhina, A. V. Abstract: The aim of this study: to assess the levels of VEGF and TNF-α in women with different outcomes of hormonal stimulation of the ovaries during the treatment of infertility using ART methods 2024-01-01T00:00:00Z