http://dspace.bsuedu.ru/handle/123456789/46277 2026-04-07T14:05:04Z http://dspace.bsuedu.ru/handle/123456789/46604 Title: Critical aspects of the management of stable coronary artery disease in primary care practice or how to increase the efficacy of evidence-based pharmacological therapy? Authors: Zyryanov, S. K.; Fitilev, S. B.; Vozzhaev, A. V.; Shkrebniova, I. I.; Klyuev, D. A. Abstract: The publication describes a fragment of the pharmacoepidemiologic study conducted to review the quality of management of patients with stable coronary artery disease (SCAD) in primary care over a 12-year period. The aim of the study was to justify the application of standard operating procedures (SOPs). Such determinants of pharmacotherapy as non-pharmacological modification of cardiovascular risk factors (RFs) and medication adherence were analyzed 2020-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/46603 Title: Review of machine learning technologies and neural networks in drug synergy combination pharmacological research Authors: Ter-Levonian, A. S.; Koshechkin, K. A. Abstract: Using machine learning (in silico) allows predicting how to get the right combination of drugs and skip the experimental steps in a study that take a lot of time and financial expenses. Gradual preparation is needed for the Deep Learning of Drug Synergy, starting from creating a base of drugs, their characteristics and ways of interacting 2020-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/46602 Title: Study of aversive and p38 mapk-inhibitory properties of kappa-agonist with analgesic activity-compound RU-1205 Authors: Spasov, A. A.; Zvartau, E. E.; Grechko, O. I.; Eliseeva, N. V.; Semenova, Yu. V. Abstract: The clinical use of kappa-opioid agonists, despite their lack of significant drug potential, is limited by the development of severe sedation, dysphoria, depression, and anhedonia. To this date, there are kappa-opioid receptor agonists lacking these side effects due to the selective activation of intracellular signal transmission pathways without p38-MAPK-kinase activation 2020-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/46592 Title: Influence of Diazepino [1,2-a] benzimidazole derivative (DAB-19) on behavioral aspects of animals Authors: Maltsev, D. V.; Spasov, A. A.; Miroshnikov, M. V.; Skripka, M. O.; Divaeva, L. N. Abstract: In the present study, compound DAB-19 was screened for its influence on animals` behavior patterns, such as aggression, obsessive-compulsive behavior, emotional lability, and unsociability 2020-01-01T00:00:00Z