http://dspace.bsuedu.ru/handle/123456789/46263 2026-04-07T14:05:17Z http://dspace.bsuedu.ru/handle/123456789/46461 Title: Optimization immunepharmacotherapy of pyoinflammatory diseases Authors: Zemskova, V. A.; Zoloedov, V. I.; Popova, O. A. Abstract: The results of clinical investigation of several pyoinflammatory diseases are presented. Objectives: On clinical data of various models of pyoinflammatory diseases - deep pyodermia (UCP), chronic salpingooforitis (OHSO), chronic pyelonephritis (CPN), authors found a significant mechanism of influence the pathogenesis on the manifestation of immunopathology, efficacy and mechanisms of pharmacological immunocorrection action 2017-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/46460 Title: The effect of new forms for external application on the vasodilating function of the endothelium and the concentration of endothelial nitric oxide synthases in rats with an experimental model of a pathological scar at early healing times Authors: Voronkov, A. V.; Gamzeleva, O. Yu. Abstract: According to statistical data, the tendency towards an increase in the number of patients with keloid and hypertrophic scars at the site of skin lesions remains in the world, which in most cases is due to the lack of effective methods for preventing this type of complications. Therefore, the development of new methods of pharmacological correction, which allow us to normalize the wound healing process at an early stage, seems very relevant. One of the promising areas for the search for substances suitable for the prevention of pathological scars is the study of natural compounds possessing endothelioprotective activity, since, according to modern ideas, it is the endothelial dysfunction that underlies the pathogenesis of this complication 2017-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/46459 Title: Effect of pharmacological preconditioning with incretinomimetics exenatide and vildagliptin on the survival of ischemic tissues Authors: Tarasova, A. P.; Danilenko, L. M.; Sernov, L. N. Abstract: Currently, much attention is paid to the pleiotropic effects of entretenimiento. Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, damage of liver and skin graft during the experiment. During the experimental study we used a comprehensive approach to the study of the antiischemic effects of entretenimento: doksorubitsinola model of cardiomyopathy, hypo/reperfusion of the isolated heart, ischemia/reperfusion of the liver and the modeling of the skin flap on the supply leg 2017-01-01T00:00:00Z http://dspace.bsuedu.ru/handle/123456789/46457 Title: Study of analeptic activity of tetrahydropyrido [2,1-b] [1,3,5] tiadiazine derivatives Authors: Bibik, E. Yu.; Saphonova, A. A.; Yeryomin, A. V.; Frolov, K. A.; Dotsenko, V. V. Abstract: Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1, 3, 5] thiadiazine derivative group. Biological studies were carried out on 78 white pedigreed mature sexually transmitted rats of both sexes weighing 230-270 g in the autumn-winter period. The test substances were administered intragastrically at a dose of 5 mg/kg 1 hour prior to the induction of anesthesia. Animals of the control group received thiopental sodium at a dose of 70 mg/kg. As the reference preparation, sodium caffeinebenzoate was used intraperitoneally at a dose of 10 mg/kg 2017-01-01T00:00:00Z