DSpace Collection: http://dspace.bsuedu.ru/handle/123456789/46285 2026-04-07T13:52:57Z 2026-04-07T13:52:57Z Development of novel effective agents from 1H-indolylammonium trifluoroacetates effective against conditionally pathogenic microorganisms Stepanenko, I. S. Yamashkin, S. A. Platkova, T. N. Kiryutina, A. I. Sorokvasha, I. N. http://dspace.bsuedu.ru/handle/123456789/46695 2022-05-13T00:07:56Z 2022-01-01T00:00:00Z Title: Development of novel effective agents from 1H-indolylammonium trifluoroacetates effective against conditionally pathogenic microorganisms Authors: Stepanenko, I. S.; Yamashkin, S. A.; Platkova, T. N.; Kiryutina, A. I.; Sorokvasha, I. N. Abstract: The problem of antibiotic resistance of microorganisms is becoming more urgent in the twenty-first century. More and more pathogenic microbes are becoming resistant to two or more antibiotics. This problem has become worse into the COVID-19 pandemic 2022-01-01T00:00:00Z Experimental study of new derivatives of 3-hydroxypyridine as pharmacological agents for the correction of ischemic brain injury after intracerebral hemorrhage Shcheblykina, O. V. Shcheblykin, D. V. Trunov, K. S. Danilenko, A. P. Lipatov, V. S. http://dspace.bsuedu.ru/handle/123456789/46693 2022-05-13T00:07:59Z 2022-01-01T00:00:00Z Title: Experimental study of new derivatives of 3-hydroxypyridine as pharmacological agents for the correction of ischemic brain injury after intracerebral hemorrhage Authors: Shcheblykina, O. V.; Shcheblykin, D. V.; Trunov, K. S.; Danilenko, A. P.; Lipatov, V. S. Abstract: Limiting the action of secondary injury factors can improve the prognosis in acute cerebral accidents. The aim of the investigation is to study the neuroprotective effects of 3-hydroxypyridine derivatives 2022-01-01T00:00:00Z Validation of structural-based virtual screening protocols with the PDB Code 3G0B and prediction of the activity of Tinospora crispa compounds as inhibitors of dipeptidyl-peptidase-IV Andri Prasetiyo Shirly Kumala Esti Mumpuni Raymond R. Tjandrawinata http://dspace.bsuedu.ru/handle/123456789/46691 2022-05-13T00:07:32Z 2022-01-01T00:00:00Z Title: Validation of structural-based virtual screening protocols with the PDB Code 3G0B and prediction of the activity of Tinospora crispa compounds as inhibitors of dipeptidyl-peptidase-IV Authors: Andri Prasetiyo; Shirly Kumala; Esti Mumpuni; Raymond R. Tjandrawinata Abstract: Brotowali (Tinospora crispa) has been traditionally used as an antidiabetic drug. DPP-IV inhibitor as an antidiabetic will increase insulin secretion. It indirectly escalates incretin hormones, such as Glucagon-Like peptide-1 (GLP-1) which depends on glucose. This study predicts potential compounds from the Brotowali plants, such as DPP-IV inhibitors, using the Molegro Virtual Docker (MVD) 2022-01-01T00:00:00Z Synthesis, molecular docking, ADMET study and in vitro pharmacological research of 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione as a promising non-opioid analgesic drug Kravchenko, A. D. Pyatigorskaya, N. V. Brkich, G. E. Yevsieieva, L. V. Kyrychenko, A. V. http://dspace.bsuedu.ru/handle/123456789/46672 2022-05-12T00:09:27Z 2022-01-01T00:00:00Z Title: Synthesis, molecular docking, ADMET study and in vitro pharmacological research of 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione as a promising non-opioid analgesic drug Authors: Kravchenko, A. D.; Pyatigorskaya, N. V.; Brkich, G. E.; Yevsieieva, L. V.; Kyrychenko, A. V. Abstract: The discovery of novel drugs that can block the transmission of pain signals for treating the pain of various etiologies is an urgent topic in pharmaceutics. The aim of this paper is to synthesize and to investigate in vitro and in silico characteristics of a promising novel compound: 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione (HSV-DKH-0450) 2022-01-01T00:00:00Z